Pegloticase (Krystexxa)
Pegloticase is a protein that is designed to treat severe chronic gout. The protein breaks down uric acid into a substance that the body can excrete. Pegloticase is indicated in patients in whom despite treatment with other medications (such as allopurinol, febuoxostat, probenecid, and other interventions) have failed to achieve the serum uric acid target, who continue to have frequent gout flares (≥2 flares/year) or who have non-resolving subcutaneous tophi.
